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  • Journal article
    Rasool N, Yasin T, Heng JYY, Akhter Zet al., 2010,

    , POLYMER, Vol: 51, Pages: 1687-1693, ISSN: 0032-3861
    • Cite
    • Citations: 137
  • Journal article
    Beale J, Lee SY, Iwata S, Beis Ket al., 2010,

    , ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, Vol: 66, Pages: 391-396
    • Cite
    • Citations: 10
  • Journal article
    Ho R, Hinder SJ, Watts JF, Dilworth SE, Williams DR, Heng JYYet al., 2010,

    , INTERNATIONAL JOURNAL OF PHARMACEUTICS, Vol: 387, Pages: 79-86, ISSN: 0378-5173
    • Cite
    • Citations: 80
  • Journal article
    Hare S, Gupta SS, Valkov E, Engelman A, Cherepanov Pet al., 2010,

    , Nature, Vol: 464, Pages: 232-236, ISSN: 0028-0836

    Integrase is an essential retroviral enzyme that binds both termini of linear viral DNA and inserts them into a host cell chromosome. The structure of full-length retroviral integrase, either separately or in complex with DNA, has been lacking. Furthermore, although clinically useful inhibitors of HIV integrase have been developed, their mechanism of action remains speculative. Here we present a crystal structure of full-length integrase from the prototype foamy virus in complex with its cognate DNA. The structure shows the organization of the retroviral intasome comprising an integrase tetramer tightly associated with a pair of viral DNA ends. All three canonical integrase structural domains are involved in extensive protein–DNA and protein–protein interactions. The binding of strand-transfer inhibitors displaces the reactive viral DNA end from the active site, disarming the viral nucleoprotein complex. Our findings define the structural basis of retroviral DNA integration, and will allow modelling of the HIV-1 intasome to aid in the development of antiretroviral drugs.
  • Journal article
    Helaine S, Thompson JA, Watson KG, Liu M, Boyle C, Holden DWet al., 2010,

    , PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 107, Pages: 3746-3751, ISSN: 0027-8424
    • Cite
    • Citations: 246
  • Journal article
    Telfer A, Pascal AA, Bordes L, Barber J, Robert Bet al., 2010,

    , JOURNAL OF PHYSICAL CHEMISTRY B, Vol: 114, Pages: 2255-2260, ISSN: 1520-6106
    • Cite
    • Citations: 14
  • Journal article
    Camara B, Liu M, Reynolds J, Shadrin A, Liu B, Kwok K, Simpson P, Weinzierl R, Severinov K, Cota E, Matthews S, Wigneshweraraj SRet al., 2010,

    , PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 107, Pages: 2247-2252, ISSN: 0027-8424
    • Cite
    • Citations: 56
  • Journal article
    Ewens CA, Kloppsteck P, Foerster A, Zhang X, Freemont PSet al., 2010,

    , BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE, Vol: 88, Pages: 41-48, ISSN: 0829-8211
    • Cite
    • Citations: 33
  • Journal article
    Chaudhuri RR, Sebaihia M, Hobman JL, Webber MA, Leyton DL, Goldberg MD, Cunningham AF, Scott-Tucker A, Ferguson PR, Thomas CM, Frankel G, Tang CM, Dudley EG, Roberts IS, Rasko DA, Pallen MJ, Parkhill J, Nataro JP, Thomson NR, Henderson IRet al., 2010,

    , PLOS ONE, Vol: 5, ISSN: 1932-6203
    • Cite
    • Citations: 144
  • Journal article
    Zunszain PA, Knox SR, Sweeney TR, Yang J, Roque-Rosell N, Belsham GJ, Leatherbarrow RJ, Curry Set al., 2010,

    , JOURNAL OF MOLECULAR BIOLOGY, Vol: 395, Pages: 375-389, ISSN: 0022-2836
    • Cite
    • Citations: 61
  • Journal article
    Khoo JY, Heng JYY, Williams DR, 2010,

    , INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, Vol: 49, Pages: 422-427, ISSN: 0888-5885
    • Cite
    • Citations: 15
  • Journal article
    Hughes S, Jenkins V, Dar MJ, Engelman A, Cherepanov Pet al., 2010,

    , JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 285, Pages: 541-554
    • Cite
    • Citations: 54
  • Journal article
    Curry S, 2010,

    , Biochemist, Vol: 32, Pages: 18-21, ISSN: 0954-982X
  • Journal article
    Thompson O, Moore CJ, Hussaina S-A, Kleino I, Peckham M, Hohenester E, Ayscough KR, Saksela K, Winder SJet al., 2010,

    , JOURNAL OF CELL SCIENCE, Vol: 123, Pages: 118-127, ISSN: 0021-9533
    • Cite
    • Citations: 50
  • Conference paper
    Robinson T, Manning HB, Dunsby C, Neil MAA, Baldwin GS, de Mello AJ, French PMWet al., 2010,

    , Conference on Microfluidics, BioMEMS, and Medical Microsystems VIII, Publisher: SPIE-INT SOC OPTICAL ENGINEERING, ISSN: 0277-786X
  • Journal article
    Vittadello M, Gorbunov MY, Mastrogiovanni DT, Wielunski LS, Garfunkel EL, Guerrero F, Kirilovsky D, Sugiura M, Rutherford AW, Safari A, Falkowski PGet al., 2010,

    , CHEMSUSCHEM, Vol: 3, Pages: 471-475, ISSN: 1864-5631
    • Cite
    • Citations: 29
  • Journal article
    Thomas JC, Green JL, Howson RI, Simpson P, Moss DK, Martin SR, Holder AA, Cota E, Tate EWet al., 2010,

    , MOLECULAR BIOSYSTEMS, Vol: 6, Pages: 494-498, ISSN: 1742-206X
    • Cite
    • Citations: 27
  • Journal article
    Ayub M, Ivanov A, Instuli E, Cecchini M, Chansin G, McGilvery C, Hong J, Baldwin G, McComb D, Edel JB, otherset al., 2010,

    Nanopore/electrode structures for single-molecule biosensing

    , Electrochimica Acta, Vol: 55, Pages: 8237-8243
  • Journal article
    Herrero C, Hughes JL, Quaranta A, Cox N, Rutherford AW, Leibl W, Aukauloo Aet al., 2010,

    , CHEMICAL COMMUNICATIONS, Vol: 46, Pages: 7605-7607, ISSN: 1359-7345
    • Cite
    • Citations: 30
  • Journal article
    Roskilly SJ, Colbourn EA, Alli O, Williams DR, Paul KA, Welfare EH, Trusty PAet al., 2010,

    Investigating the effect of shape on particle segregation using aMonte Carlo simulation

    , Powder Technology, Vol: 203, Pages: 211-222

    A Monte Carlo simulation has been used to investigate the segregation potential of a range of particulate systems under conditions in which the particles undergo high amplitude low frequency shaking. These systems involve a wide range of binary powder mixtures in which complex particle shapes have been investigated, including plates and rods which represent the real world materials encountered in pharmaceutical systems such as those which include crystalline components. Previous simulations on the segregation propensity of systems with different shapes were limited to spheres and spherocylinders, with relatively low vibrational amplitude drops. A commercial computer application for particle packing—calledMacroPac—has been successfully employed here, as it has been able to model systems that are more complex where the shape variation is much wider. These simulations apply to the case of macroscopic particles, in the absence of air resistance and inter-particle forces. For non-spherical shapes, an ‘effective size’ which relates to the radius of gyration of the particles is determined. Our studies indicate that with high amplitude low frequency shaking, in a mixture of particles with different shapes but with equal volumes, the particles with the larger ‘effective size’, which tend to have a lower packing fraction, segregate to the top
  • Journal article
    Low HH, Sachse C, Amos LA, Lowe Jet al., 2009,

    , CELL, Vol: 139, Pages: 1342-1352, ISSN: 0092-8674
    • Cite
    • Citations: 149
  • Journal article
    Douzi B, Durand E, Bernard C, Alphonse S, Cambillau C, Filloux A, Tegoni M, Voulhoux Ret al., 2009,

    , JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 284, Pages: 34580-34589
    • Cite
    • Citations: 52
  • Journal article
    Carafoli F, Bihan D, Stathopoulos S, Konitsiotis AD, Kvansakul M, Farndale RW, Leitinger B, Hohenester Eet al., 2009,

    , STRUCTURE, Vol: 17, Pages: 1573-1581, ISSN: 0969-2126
    • Cite
    • Citations: 115
  • Journal article
    Eswaran J, Patnaik D, Filippakopoulos P, Wang F, Stein RL, Murray JW, Higgins JMG, Knapp Set al., 2009,

    , PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 106, Pages: 20198-20203, ISSN: 0027-8424
    • Cite
    • Citations: 133
  • Journal article
    Nicastro G, Masino L, Esposito V, Menon RP, De Simone A, Fraternali F, Pastore Aet al., 2009,

    , BIOPOLYMERS, Vol: 91, Pages: 1203-1214, ISSN: 0006-3525
    • Cite
    • Citations: 76
  • Journal article
    Listorti A, Durrant J, Barber J, 2009,

    , NATURE MATERIALS, Vol: 8, Pages: 929-U22, ISSN: 1476-1122
    • Cite
    • Citations: 217
  • Journal article
    Bulgin R, Arbeloa A, Goulding D, Dougan G, Crepin VF, Raymond B, Frankel Get al., 2009,

    , PLOS PATHOGENS, Vol: 5, ISSN: 1553-7366
    • Cite
    • Citations: 45
  • Journal article
    De Simone A, Cavalli A, Hsu S-TD, Vranken W, Vendruscolo Met al., 2009,

    , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol: 131, Pages: 16332-+, ISSN: 0002-7863
    • Cite
    • Citations: 81
  • Journal article
    Baier J, Gabrielsen M, Oellerich S, Michel H, van Heel M, Cogdell RJ, Koehler Jet al., 2009,

    , BIOPHYSICAL JOURNAL, Vol: 97, Pages: 2604-2612, ISSN: 0006-3495
    • Cite
    • Citations: 22
  • Journal article
    Chim N, McMath LM, Beeby M, Goulding CWet al., 2009,

    Advances in Mycobacterium tuberculosis structural genomics: investigating potential chinks in the armor of a deadly pathogen

    , Infect Disord Drug Targets, Vol: 9, Pages: 475-492

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