In this section
@article{Del:2026:brain/awag312,
author = {Del, Giovane M and Darvishi, V and David, MCB and Kolanko, MA and Scott, G and Zimmerman, KA and Giunchiglia, V and Gontsarova, A and Hampshire, A and Malhotra, PA and Ghajari, M and Carswell, C and Sharp, DJ},
doi = {brain/awag312},
journal = {Brain},
title = {Modelling the effect of ventricular expansion on white matter in normal pressure hydrocephalus.},
url = {http://dx.doi.org/10.1093/brain/awag312},
year = {2026}
}
TY - JOUR
AB - The mechanism by which idiopathic normal pressure hydrocephalus (iNPH) causes cognitive impairment, gait dysfunction and urinary incontinence is unclear. The key radiological feature is ventriculomegaly, and symptoms can be treated with surgery. We hypothesise that ventricular expansion causes clinical effects by stretching and/or compressing white matter tracts. We define disease-specific white matter abnormalities, explore their relationship to clinical features and test whether they can be explained by a computational model of ventricular expansion in iNPH. In this observational study, diffusion tensor imaging with Tract-Based Spatial Statistics analysis was used to investigate white matter abnormalities in 22 patients with iNPH (14 males, mean age=71.91, SD=7.06), 28 with Alzheimer's disease (AD) (18 males, mean age=74.80), 23 with moderate-severe traumatic brain injury (TBI) (15 males, mean age=69.87) and 30 healthy controls (16 males, mean age=73.80). We developed a finite-element biomechanical model of hydrocephalus, which predicts patterns of white matter stretch and compression generated to deform from healthy to iNPH brain, and studied their effect on the extracted diffusion properties. Increased ventricular size relative to controls was found in both iNPH, AD and TBI. However, iNPH showed a unique pattern of increased and decreased fractional anisotropy (FA) in distinct sections of the corticospinal tract and corona radiata compared to AD, TBI and controls. Biomechanical modelling revealed that stretch in these tracts was associated with increased FA, driven by increased axial diffusivity (AxD) with little change or a reduction in radial diffusivity (RD). In contrast, compression was associated with reduced FA, resulting from increases in both AxD and RD. Parcel-based correlation analysis showed that strain predicted by the biomechanical model in these tracts was strongly and positively correlated with FA and negatively correlated with RD. The corpus call
AU - Del,Giovane M
AU - Darvishi,V
AU - David,MCB
AU - Kolanko,MA
AU - Scott,G
AU - Zimmerman,KA
AU - Giunchiglia,V
AU - Gontsarova,A
AU - Hampshire,A
AU - Malhotra,PA
AU - Ghajari,M
AU - Carswell,C
AU - Sharp,DJ
DO - brain/awag312
PY - 2026///
TI - Modelling the effect of ventricular expansion on white matter in normal pressure hydrocephalus.
T2 - Brain
UR - http://dx.doi.org/10.1093/brain/awag312
UR - https://www.ncbi.nlm.nih.gov/pubmed/42740517
ER -