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@article{Anand:2026:10.1038/s42003-026-10541-0,
author = {Anand, PK and Aljadeed, NM},
doi = {10.1038/s42003-026-10541-0},
journal = {Communications Biology},
title = {Spatial control of NLRP3 inflammasome assembly by membrane lipid composition},
url = {http://dx.doi.org/10.1038/s42003-026-10541-0},
volume = {9},
year = {2026}
}
TY - JOUR
AB - The NLRP3 inflammasome has been shown to assemble on multiple organelles, including the mitochondria, endoplasmic reticulum, trans-Golgi network, and endosomes. Yet, the precise site of assembly remains unresolved. Emerging evidence suggests that membrane lipid composition may play a critical role with phosphoinositides, cholesterol, and cardiolipin, alongside membrane biophysical properties and cellular metabolic state, collectively shaping membranes where inflammasome assembles. Here, we review how lipid-dependent mechanisms regulate NLRP3 assembly across membranes and consider whether a defined membrane lipid signature governs inflammasome assembly. This understanding may have broader implications for therapeutic targeting in inflammatory and metabolic diseases.
AU - Anand,PK
AU - Aljadeed,NM
DO - 10.1038/s42003-026-10541-0
PY - 2026///
SN - 2399-3642
TI - Spatial control of NLRP3 inflammasome assembly by membrane lipid composition
T2 - Communications Biology
UR - http://dx.doi.org/10.1038/s42003-026-10541-0
UR - https://doi.org/10.1038/s42003-026-10541-0
VL - 9
ER -