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@article{Yuen:2026:10.1186/s42483-026-00462-5,
author = {Yuen, ELH},
doi = {10.1186/s42483-026-00462-5},
journal = {Phytopathology Research},
title = {A splicing checkpoint couples surface and intracellular plant immunity},
url = {http://dx.doi.org/10.1186/s42483-026-00462-5},
volume = {8},
year = {2026}
}
TY - JOUR
AB - Plant immunity operates through two interconnected layers. Pattern-triggered immunity (PTI) is initiated by cell-surface pattern-recognition receptors, whereas effector-triggered immunity (ETI) is executed by intracellular nucleotide-binding leucine-rich repeat (NLR) receptors. The two layers are known to potentiate one another, yet how a signal perceived at the plasma membrane is relayed to prime an intracellular NLR has remained unclear. In a recent study, Gao et al. (2026) show that the potato late blight resistance protein Rpi-vnt1.1 carries a self-imposed restraint, an autoinhibitory N-terminal extension encoded by an intron-retained mRNA isoform. Pathogen perception, acting through PTI, shifts the balance of alternative splicing towards an isoform that lacks this extension, producing a resistosome-competent receptor that the Phytophthora infestans effector AVRvnt1 can then activate. This work defines pre-mRNA alternative splicing as a checkpoint that couples surface and intracellular immunity, and points to a broadly conserved and engineerable mode of NLR control.
AU - Yuen,ELH
DO - 10.1186/s42483-026-00462-5
PY - 2026///
SN - 2096-5362
TI - A splicing checkpoint couples surface and intracellular plant immunity
T2 - Phytopathology Research
UR - http://dx.doi.org/10.1186/s42483-026-00462-5
VL - 8
ER -
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