BibTex format
@article{Vano:2026:schbul/sbag045,
author = {Vano, LJ and Sedlacik, J and Kaar, SJ and Rutigliano, G and Carr, R and Berry, A and Statton, B and Fazlollahi, A and Veronese, M and Howes, OD and McCutcheon, RA},
doi = {schbul/sbag045},
journal = {Schizophr Bull},
title = {Cortical Iron and Mesostriatal Dopamine Function in Schizophrenia: A Positron Emission Tomography and Magnetic Resonance Imaging Study.},
url = {http://dx.doi.org/10.1093/schbul/sbag045},
volume = {52},
year = {2026}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - BACKGROUND AND HYPOTHESIS: Elevated postmortem iron in Brodmann areas 10-11 has recently been linked to schizophrenia. Although in vivo studies have linked subcortical iron abnormalities to disease-related striatal hyperdopaminergia, in vivo cortical iron alterations have not been previously examined. We therefore used neuroimaging to test whether cortical iron is elevated in individuals with schizophrenia and whether this correlated with mesostriatal dopamine function. STUDY DESIGN: We acquired quantitative susceptibility mapping magnetic resonance imaging (MRI) to measure magnetic susceptibility (χ), a marker of iron, in 149 participants aged 18-45 (73 with schizophrenia and 76 matched healthy controls). Subsets of patients with schizophrenia underwent [18F]-DOPA PET to estimate striatal dopamine synthesis capacity (n = 39) and neuromelanin-sensitive MRI of the dopaminergic midbrain (n = 68), as neuromelanin is a byproduct of dopamine synthesis. STUDY RESULTS: Primary analyses showed no significant case-control differences in χ in the whole cortex (P = .675) or Brodmann areas 10-11 (P = .537). Exploratory analyses examined χ for 360 cortical regions, correcting for multiple comparisons. Two left temporo-parieto-occipital junction regions showed significantly elevated χ in schizophrenia: the posterior temporo-parieto-occipital junction the posterior temporo-parieto-occipital junction (d = 0.752, P < .001) and the superior temporal visual area (d = 0.638, P = .034). Mean χ across these regions inversely correlated with dopamine synthesis capacity in the associative (r = -0.37, P = .048) and limbic (r = -0.34, P = .048) striatum, and with neuromelanin-sensitive MRI values in the dopaminergic midbrain (r = -0.35, P = .005), corrected for multiple comparisons. CONCLUSIONS: This stu
AU - Vano,LJ
AU - Sedlacik,J
AU - Kaar,SJ
AU - Rutigliano,G
AU - Carr,R
AU - Berry,A
AU - Statton,B
AU - Fazlollahi,A
AU - Veronese,M
AU - Howes,OD
AU - McCutcheon,RA
DO - schbul/sbag045
PY - 2026///
TI - Cortical Iron and Mesostriatal Dopamine Function in Schizophrenia: A Positron Emission Tomography and Magnetic Resonance Imaging Study.
T2 - Schizophr Bull
UR - http://dx.doi.org/10.1093/schbul/sbag045
UR - https://www.ncbi.nlm.nih.gov/pubmed/42487413
VL - 52
ER -