Aug 2016 - Article in Chem. Sci. Published
A review of Suzuki-Miyaura cross-coupling reactions of heteroaryl polyhalides with aryl boronates is published
Joshua Almond-Thynne David C. Blakemore, David C. Pryde and Alan C. Spivey, 'Site-selective Suzuki-Miyaura Coupling of Heteroaryl Halides - Understanding the Trends for Pharmaceutically Important Cases', Chem. Sci. 2017, 8, 40 - 62. DOI:
Suzuki-Miyaura cross-coupling reactions of heteroaryl polyhalides with aryl boronates are surveyed. Drawing on data from literature sources as well as bespoke searches of Pfizer’s global chemistry RKB and CAS Scifinder® databases, the factors that determine the site-selectivity of these reactions are discussed with a view to rationalising the trends found.
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Reporter
Professor Alan C Spivey
Department of Chemistry