Nature Reviews Cancer: Protein Lipidation
Protein N-Myristoylation relating to cancer
Ed, Ana and Lior, together with co-authors Prof Hening Lin (Cornell) and Prof Mei Wang-Casey (NUS Singapore) have published a review in Nature Reviews
In the first unified review on protein lipidation in , they review the oncogenic roles and drug target potential of the enzymes and other proteins regulating each of the main classes of protein lipidation: myristoylation, palmitoylation (or S-acylation), prenylation and secreted protein lipidation (Hedgehog and Wnt proteins). They discuss the direct impact on tumorigenesis and importance in the immune response to cancer, and highlight the potential to target lipidation inhibitors through advanced therapeutic approaches, including several topics central to research in the Tate lab. These include , the recently discovered , new approaches to , and the NMT inhibitor-armed antibody-drug conjugates (ADCs) being developed by .
We hope this review offers a useful perspective of the current state of the art for this important and emerging class of cancer and immuno-oncology drug targets.
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Dr Thomas J Burden
Department of Chemistry
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