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  • Journal article
    Whyte GP, Stephens N, Senior R, Peters N, O'Hanlon R, Sharma Set al., 2008,

    , MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, Vol: 40, Pages: 1357-1361, ISSN: 0195-9131
    • Cite
    • Citations: 13
  • Journal article
    Ciaccio EJ, Chow AW, Kaba RA, Davies DW, Segal OR, Peters NSet al., 2008,

    , HEART RHYTHM, Vol: 5, Pages: 981-991, ISSN: 1547-5271
    • Cite
    • Citations: 30
  • Journal article
    Kanagaratnam P, Koa-Wing M, Peters NS, 2008,

    Catheter ablation in patients with ICDs

    , NEW ENGLAND JOURNAL OF MEDICINE, Vol: 358, Pages: 2295-2295, ISSN: 0028-4793
  • Journal article
    Kontogeorgis A, Kaba RA, Kang E, Feig JE, Gupta PP, Ponzio M, Liu F, Rindler MJ, Wit AL, Fisher EA, Peters NS, Gutstein DEet al., 2008,

    , BMC Physiology, Vol: 8, ISSN: 1472-6793

    BACKGROUND: Cardiac insults such as ischemia, infarction, hypertrophy and dilatation are often accompanied by altered abundance and/or localization of the connexin43 gap junction protein, which may predispose towards arrhythmic complications. Models of chronic dyssynchronous cardiac activation have also been shown to result in redistribution of connexin43 in cardiomyocytes. We hypothesized that alterations in connexin43 expression and localization in the mouse heart might be induced by ventricular pacing over a short period of time. RESULTS: The subdiaphragmatic approach was used to pace a series of wild type mice for six hours before the hearts were removed for analysis. Mice were paced at 10-15% above their average anesthetized sinus rate and monitored to ensure 1:1 capture. Short-term pacing resulted in a significant reduction in connexin43 mRNA abundance, a partial redistribution of connexin43 from the sarcolemma to a non-sarcolemmal fraction, and accumulation of ubiquitinated connexin43 without a significant change in overall connexin43 protein levels. These early pacing-induced changes in connexin43 expression were not accompanied by decreased cardiac function, prolonged refractoriness or increased inducibility into sustained arrhythmias. CONCLUSION: Our data suggest that short-term pacing is associated with incipient changes in the expression of the connexin43 gap junction, possibly including decreased production and a slowed rate of degradation. This murine model may facilitate the study of early molecular changes induced by pacing and may ultimately assist in the development of strategies to prevent gap junction remodeling and the associated arrhythmic complications of cardiac disease.
  • Journal article
    Stuber T, Lim PB, O'Neill MD, Peters NSet al., 2008,

    , JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, Vol: 19, Pages: 566-567, ISSN: 1045-3873
  • Journal article
    Kanagaratnam P, Kojodjojo P, Peters NS, 2008,

    , PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, Vol: 31, Pages: 443-453, ISSN: 0147-8389
    • Cite
    • Citations: 17
  • Journal article
    Whinnett ZI, Briscoe C, Davies JE, Willson K, Manisty CH, Davies DW, Peters NS, Kanagaratnam P, Hughes AD, Mayet J, Francis DPet al., 2008,

    , Heart Rhythm, Vol: 5, Pages: 378-386, ISSN: 1547-5271

    Atrioventricular (AV) optimization of cardiac resynchronization therapy (CRT) is typically calculated at rest. However, patients often become symptomatic during exercise.
  • Journal article
    Wright M, O'Neill MD, Wright DPI, Peters NS, Davies W, Kanagaratnam Pet al., 2008,

    , JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, Vol: 19, Pages: 217-218, ISSN: 1045-3873
  • Journal article
    Sampson KJ, Terrenoire C, Cervantes DO, Kaba RA, Peters NS, Kass RSet al., 2008,

    , JOURNAL OF PHYSIOLOGY-LONDON, Vol: 586, Pages: 627-637, ISSN: 0022-3751
    • Cite
    • Citations: 31
  • Journal article
    Kanagaratnam P, Koa-Wing M, Wallace DT, Goldenberg AS, Peters NS, Davies DWet al., 2008,

    , JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY, Vol: 21, Pages: 19-26, ISSN: 1383-875X
    • Cite
    • Citations: 138

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