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• Journal article
  Ng FS, Shadi IT, Peters NS, Lyon ARet al., 2013,
  , JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, Vol: 59, Pages: 67-75, ISSN: 0022-2828
  • Cite
  • Citations: 26
• Journal article
  Hunter RJ, Jones DA, Boubertakh R, Malcolme-Lawes LC, Kanagaratnam P, Juli CF, Davies DW, Peters NS, Baker V, Earley MJ, Sporton S, Davies LC, Westwood M, Petersen SE, Schilling RJet al., 2013,
  , JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, Vol: 24, Pages: 396-403, ISSN: 1045-3873
  • Cite
  • Citations: 60
• Journal article
  Hayat SA, Kojodjojo P, Mason A, Benfield A, Wright I, Whinnett Z, Lim PB, Davies DW, Lefroy D, Peters NS, Kanagaratnam Pet al., 2013,
  , JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, Vol: 24, Pages: 351-355, ISSN: 1045-3873
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  • Citations: 2
• Journal article
  Ware JS, John S, Roberts AM, Buchan R, Gong S, Peters NS, Robinson DO, Lucassen A, Behr ER, Cook SAet al., 2013,
  , JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, Vol: 6, Pages: 94-103, ISSN: 1937-5387
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  • Citations: 27
• Journal article
  Malcolme-Lawes LC, Lim PB, Koa-Wing M, Whinnett ZI, Jamil-Copley S, Hayat S, Francis DP, Kojodjojo P, Davies DW, Peters NS, Kanagaratnam Pet al., 2013,
  , EUROPACE, Vol: 15, Pages: 41-47, ISSN: 1099-5129
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  • Citations: 21
• Journal article
  Kyriacou A, Whinnett ZI, Sen S, Pabari PA, Wright I, Cornelussen R, Lefroy D, Davies DW, Peters NS, Kanagaratnam P, Mayet J, Hughes AD, Francis DP, Davies JEet al., 2012,
  , CIRCULATION, Vol: 126, Pages: 1334-+, ISSN: 0009-7322
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  • Citations: 30
• Journal article
  Paur H, Wright PT, Sikkel MB, Tranter MH, Mansfield C, O'Gara P, Stuckey DJ, Nikolaev VO, Diakonov I, Pannell L, Gong H, Sun H, Peters NS, Petrou M, Zheng Z, Gorelik J, Lyon AR, Harding SEet al., 2012,
  , Circulation Journal, Vol: 6, Pages: 697-706
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• Journal article
  Jarman JW, Wong T, Kojodojojo P, Sophr H, Davies JE, Roughton M, Francis DP, Kanagaratnam P, Markides V, Davies DW, Peters NSet al., 2012,
  , Circ Arrhythm Electrophysiol., Vol: 4, Pages: 650-658

  BACKGROUNDSites of high dominant frequency (DF(peak)) are thought to indicate the location of drivers of atrial fibrillation (AF), but characterization of their spatiotemporal distribution and stability, critical to their relevance as targets for catheter ablation, requires simultaneous global mapping of the left atrium.METHODS AND RESULTS:Noncontact electrograms recorded simultaneously from 256 left atrial sites during spontaneous AF were analyzed. After subtraction of the ventricular component, fast Fourier transform identified the DF at each site. Focal areas of DF(peak) were defined as those having a DF >20% above all neighboring sites. Twenty-four patients with spontaneous AF (11 paroxysmal and 13 persistent) were studied. In paroxysmal AF, sites of DF(peak) (mean DF, 11.6±2.9 Hz) were observed in 100% of patients (present during 65% of the mapping period). In contrast, DF(peak) was detected in only 31% of patients with persistent AF (P<0.001) and for only 5% of the mapping period (P<0.001). In both groups, locations of DF(peak) varied widely in both consecutive and separated segments of AF (κ coefficient range, -0.07-0.22). Activation sequences around sites of DF(peak) did not demonstrate centrifugal activation that would be expected from focal drivers.CONCLUSIONS:Focal areas of high DF are more frequent in paroxysmal than persistent AF, are spatiotemporally unstable, are not the source of centrifugal activation, and are not, therefore, indicative of fixed drivers of AF. In the absence of spatiotemporal stability, the success of ablation at sites of DF(peak) cannot be explained by elimination of fixed drivers.

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• Journal article
  Jarman JW, Wong T, Kojodjojo P, Spohr H, Davies JE, Roughton M, Francis DP, Kanagaratnam P, Markides V, Davies DW, Peters NSet al., 2012,
  , Circ Arrhythm Electrophysiol, Vol: 5, Pages: 650-658, ISSN: 1941-3149
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• Journal article
  Tondato F, Robinson K, Cui J, Goodchild T, Chronos N, Peters NSet al., 2012,
  , JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, Vol: 5, Pages: 337-344, ISSN: 1937-5387
  • Cite
  • Citations: 4

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