BibTex format
@article{Lai:2026:10.1183/23120541.01158-2025,
author = {Lai, K and Xu, T and Chen, P and Lin, J and Liu, C and Wang, C and Zhou, X and Zhao, J and Shen, H and Zhou, M and Zhang, J and Liao, X and Geng, X and Wu, F and Gao, B and Qiu, C and Zhang, Y and Jin, M and Ye, X and Chen, L and He, Q and Su, X and Fan, X and Shi, G and Bai, C and Wang, G and Yi, F and Jiang, M and Chen, R and Chung, KF and Zhong, N},
doi = {10.1183/23120541.01158-2025},
journal = {ERJ Open Res},
title = {Characteristics and management of asthma from the China Asthma Data Registry Project.},
url = {http://dx.doi.org/10.1183/23120541.01158-2025},
volume = {12},
year = {2026}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - BACKGROUND: There is limited information available on patients with asthma in hospitals in China. We investigated their clinical and phenotypic characteristics and management. METHODS: The China Asthma Data Registry Project (CHART) study is a multicentre, hospital-based, prospective, observational study in which patients were recruited from outpatient clinics. This analysis used baseline cross-sectional data from patients with asthma (≥12years) enrolled at 58 tertiary hospitals in China between 25 March 2018 and 11 July 2019. RESULTS: A total of 20 683 patients with asthma (56.2% female, 15.0% patients with active tobacco use) were enrolled. Overall, 22.8% had uncontrolled asthma, 39.5% had partially controlled asthma. Furthermore, 45.3% experienced ≥1 exacerbation annually, including 31.7% who required hospitalisation, with only 21.4% having previously used inhaled corticosteroids (ICSs) in the past year. Cough (80.0%) was the most common symptom, followed by wheezing (70.7%), with 14.6% having cough-predominant asthma and 11.4% having cough-variant asthma. Multivariate logistic regression revealed that cough severity independently predicted poor control, irrespective of airflow limitation or inflammatory status. The association was stronger in ICS users than in nonusers across all cough severity metrics: a visual analogue scale (VAS) score ≥40 (aOR 3.88-5.47 versus 2.49-2.94), a cough evaluation test (CET) score ≥12 (aOR 11.15-20.91 versus 3.97-5.55), and a Leicester Cough Questionnaire (LCQ) score <15 (aOR 6.15-13.66 versus 2.45-3.18). CONCLUSIONS: We found significant suboptimal control, a high prevalence of cough-related phenotypes, frequent exacerbations and hospital admissions in patients with asthma attending hospitals. This underscores the need to prioritise the assessment and treatment of cough in asthma.
AU - Lai,K
AU - Xu,T
AU - Chen,P
AU - Lin,J
AU - Liu,C
AU - Wang,C
AU - Zhou,X
AU - Zhao,J
AU - Shen,H
AU - Zhou,M
AU - Zhang,J
AU - Liao,X
AU - Geng,X
AU - Wu,F
AU - Gao,B
AU - Qiu,C
AU - Zhang,Y
AU - Jin,M
AU - Ye,X
AU - Chen,L
AU - He,Q
AU - Su,X
AU - Fan,X
AU - Shi,G
AU - Bai,C
AU - Wang,G
AU - Yi,F
AU - Jiang,M
AU - Chen,R
AU - Chung,KF
AU - Zhong,N
DO - 10.1183/23120541.01158-2025
PY - 2026///
SN - 2312-0541
TI - Characteristics and management of asthma from the China Asthma Data Registry Project.
T2 - ERJ Open Res
UR - http://dx.doi.org/10.1183/23120541.01158-2025
UR - https://www.ncbi.nlm.nih.gov/pubmed/42311876
VL - 12
ER -