BibTex format
@article{Saunders:2026:10.1002/jmri.70368,
author = {Saunders, LC and Collier, GJ and Smith, LJ and Chan, H-F and Hughes, PJC and Strickland, S and Gustafsson, L and Newman, T and Plowright, M and Gabriel, Z and Pearce, LM and Grist, JT and Ng, KL and Harrison, A and Bolton, CE and Bray, J and Marshall, H and Norquay, G and Biancardi, AM and Ball, JE and Stewart, NJ and Johnson, KM and Swift, AJ and Rajaram, S and Blaikley, J and Stanel, S and Collini, PJ and Mills, GH and Lawson, R and Brooke, J and Goodwin, AT and Stewart, ID and Ho, L-P and Jacob, J and Meersmann, T and Pavlovskaya, GE and Gleeson, F and Hall, IP and Jenkins, G and Wild, JM and Thompson, AAR and UKILD, consortium},
doi = {10.1002/jmri.70368},
journal = {J Magn Reson Imaging},
title = {Longitudinal 1H and 129Xe Lung MRI in Patients With Post-COVID Residual Lung Abnormalities.},
url = {http://dx.doi.org/10.1002/jmri.70368},
year = {2026}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - BACKGROUND: It is unclear how lung function may recover in patients with residual lung abnormalities (RLAs) following COVID-19 pneumonia. PURPOSE: To evaluate lung function trends over time in patients with RLAs following hospitalization due to COVID-19. STUDY TYPE: Prospective, multicenter longitudinal cohort study. POPULATION: Twenty-four participants hospitalized due to COVID-19 with RLAs identified on CT ≥ 3 months postdischarge (median [IQR] age 69 (15) years; 3 female) underwent at least one MRI at 6 months (n = 16), 1 year (n = 19), or 2 years (n = 14). FIELD STRENGTH/SEQUENCE: 1.5 T. Dynamic contrast enhanced (DCE) 3D spoiled gradient echo, 129Xe steady state free precession (ventilation), 129Xe 3D spoiled gradient echo multiple b-value (diffusion-weighted), 129Xe 4-echo flyback 3D radial (dissolved phase). ASSESSMENT: Pulmonary blood flow, volume, and mean transit time (MTT) were calculated from DCE MRI. The fraction of 129Xe signal in the red blood cells to membrane (RBC:M) was calculated from the dissolved phase 129Xe acquisition. Ventilation defect percentage (VDP) was calculated from the 129Xe ventilation acquisition. Mean diffusive length scale (LmD) was calculated from the 129Xe diffusion-weighted acquisition. STATISTICAL TESTS: Changes in metrics with time and associations between metrics were assessed using mixed-effect linear regression. Correlations were tested using Spearman's correlation coefficient. Regional differences were assessed using a Friedman's test with a Bonferroni adjustment. p < 0.05 was considered significant. RESULTS: Pulmonary blood flow and MTT improved significantly over time (MTT: 6 months, 15.3 (IQR, 2.0); 1 year, 15.6 (1.4); 2 years, 15.0 (5.3); pulmonary blood flow: 6 months, 75.4 (IQR, 22.0); 1 year, 83.2 (47.4); 2 years, 107.3 (51.1)). RBC:M z-score was low at all three visits (
AU - Saunders,LC
AU - Collier,GJ
AU - Smith,LJ
AU - Chan,H-F
AU - Hughes,PJC
AU - Strickland,S
AU - Gustafsson,L
AU - Newman,T
AU - Plowright,M
AU - Gabriel,Z
AU - Pearce,LM
AU - Grist,JT
AU - Ng,KL
AU - Harrison,A
AU - Bolton,CE
AU - Bray,J
AU - Marshall,H
AU - Norquay,G
AU - Biancardi,AM
AU - Ball,JE
AU - Stewart,NJ
AU - Johnson,KM
AU - Swift,AJ
AU - Rajaram,S
AU - Blaikley,J
AU - Stanel,S
AU - Collini,PJ
AU - Mills,GH
AU - Lawson,R
AU - Brooke,J
AU - Goodwin,AT
AU - Stewart,ID
AU - Ho,L-P
AU - Jacob,J
AU - Meersmann,T
AU - Pavlovskaya,GE
AU - Gleeson,F
AU - Hall,IP
AU - Jenkins,G
AU - Wild,JM
AU - Thompson,AAR
AU - UKILD,consortium
DO - 10.1002/jmri.70368
PY - 2026///
TI - Longitudinal 1H and 129Xe Lung MRI in Patients With Post-COVID Residual Lung Abnormalities.
T2 - J Magn Reson Imaging
UR - http://dx.doi.org/10.1002/jmri.70368
UR - https://www.ncbi.nlm.nih.gov/pubmed/42210667
ER -
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