Citation

BibTex format

@article{Henderson:2026:10.1111/hiv.70236,
author = {Henderson, M and Dutey-Magni, P and Herrera, C and Stöhr, W and Arenas-Pinto, A and Swann, O and Heslegrave, A and Zetterberg, H and Tregoning, J and Fidler, S and Raffi, F and Calcagno, A and Babiker, A and Winston, A},
doi = {10.1111/hiv.70236},
journal = {HIV Med},
title = {Longitudinal changes in plasma biomarkers of immune activation, neuronal inflammation and injury in persons with HIV initiating ART.},
url = {http://dx.doi.org/10.1111/hiv.70236},
year = {2026}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Data on changes in biomarkers of brain health, and their associations with cognitive function in adults commencing either dual- or triple-antiretroviral therapy (ART) are sparse. METHODS: Plasma biomarkers (neurofilament light [NfL], glial fibrillary acidic protein [GFAP], sCD14, CXCL10, neopterin and IL-6) were measured at baseline and after 96 weeks on ART in individuals randomized to darunavir/ritonavir and either tenofovir-DF/emtricitabine (triple-ART, n = 119) or raltegravir (dual-ART, n = 119) in NEAT-001/ANRS143. Regression models examined associations of baseline and week-96 biomarker concentrations with HIV clinical parameters, composite cognitive test scores (Standardized neuropsychological test [NPZ], 7-domains) and treatment arm. RESULTS: In 238 individuals, median age was 38 (interquartile range [IQR] 31, 46) years, 87% male and 83% of white ethnicity. Baseline median log10 HIV RNA 4.73 (IQR 4.23, 5.11) copies/mL and CD4 350 (IQR 285, 412) cells/mm3. At baseline, higher biomarker concentrations were associated with lower CD4 (NfL, GFAP, CXCL10; p < 0.03), higher log10 HIV RNA (sCD14, neopterin, CXCL10; p < 0.02) and longer known duration of HIV (sCD14; p = 0.044). At week-96, 94% had plasma HIV <50 copies/mL, and a decline in biomarker concentrations was observed: GFAP -14.4%, sCD14 -6.8%, neopterin -47.4%, CXCL10 -58.8%, IL-6 -29.5% (all p < 0.001) and NfL -4.4% (p = 0.075). NPZ improved by 0.21 mean points. Change in GFAP, CXCL10, sCD14, neopterin and NfL was negatively associated with change in CD4 (all p ≤ 0.002) but not change in NPZ (p > 0.05). A greater decline in neopterin concentration was observed with dual- (-50.2%) versus triple-ART (-44.3%; p = 0.022). CONCLUSIONS: Plasma biomarkers of brain health improved following ART initiation, associated predominantly wi
AU  - Henderson,M
AU  - Dutey-Magni,P
AU  - Herrera,C
AU  - Stöhr,W
AU  - Arenas-Pinto,A
AU  - Swann,O
AU  - Heslegrave,A
AU  - Zetterberg,H
AU  - Tregoning,J
AU  - Fidler,S
AU  - Raffi,F
AU  - Calcagno,A
AU  - Babiker,A
AU  - Winston,A
DO  - 10.1111/hiv.70236
PY  - 2026///
TI  - Longitudinal changes in plasma biomarkers of immune activation, neuronal inflammation and injury in persons with HIV initiating ART.
T2  - HIV Med
UR  - http://dx.doi.org/10.1111/hiv.70236
UR  - https://www.ncbi.nlm.nih.gov/pubmed/41991901
ER  -
Download