Title:ÌýFrequency Spectra and the Colour of Cellular Noise
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Abstract:ÌýNowadays scientists can track single-cell activity for a variety of cell-types. TheÌýdynamical fluctuations inÌýmeasured single-cell trajectories contain valuable informationÌýabout the underlying stochastic reaction network. We shall discuss how frequency domain analysis provides a viable approach for gleaning this information. We provide computational approaches for reliably estimating the power spectral density (PSD) for single-cell trajectories generated by stochastic reaction networks and we demonstrate how such estimates can be used in systems and synthetic biology applications.