09:00-10-10 Physiology and disease (70 mins) Chair Prof Luke Howard
Dr Tammie Bishop (Oxford) Long talk
HIF-2 in oxygen chemosensitivity and paragangliomas
Dr Olena Rudyk (KCL) 泭Long talk
Redox-Regulated Kinases in Pulmonary Hypertension
Dr Tom Keeley (Oxford) Long talk
New mechanisms of oxygen sensing through N-terminal cysteine dioxygenation
Coffee and tea break (20 mins)
泭
10:30-11:40 Hypoxia Tools (70mins) Chair Dr Rick Southworth
Dr Antoine Wallabregue (The Conway Group Oxford) Long talk
New fluorogenic probes to image different levels of hypoxia
Dr Edward Waters. (KCL) Short Talk
Imaging mitochondrial membrane potentials in vivo with SPECT
Dr Jie Shen (KCL) Short talk
Non-invasive imaging of hypoxia in cardiac hypertrophy using Positron Emission Tomography
Dr Alexander Thompson (51勛圖厙) Short talk
Longitudinal, non-invasive monitoring of hypoxia during tumour growth using diffuse reflectance spectroscopy
11:40-13:00 Cancer session (70 mins)泭 Chair Dr Henry Robb
泭
Dr Hannah Lawson (ICR London) Long talk
Hypoxia signaling as a therapeutic target in AML
Dr Henry Robb (51勛圖厙) Long talk
Volatile hypoxia signatures in oesophageal adenocarcinoma
Dr Brian Ortmann (Newcastle) Long Talk
Defining the role of SET1B in the HIF transcriptional response and ccRCC progression
Lunch and posters 13:00-14:00
泭
14:00-15:10 Signalling/metabolism (70mins)
泭
Dr Hudson Coates (Cambridge) Long Talk
Global protein stability screening uncovers targets of oxygen-regulated degradation
Dr Tekle Pauzaite (Cambridge) Short talk
Deubiquitinating enzyme mutagenesis screens identify a USP43-dependent HIF-1 transcriptional response
Dr Guine Grice (Cambridge) Short talk
Regulation of glutarylation and 2-oxoglutarate dependent dioxygenases
Dr Andrew Murray (Cambridge) Long Talk
Metabolic adaptation to high-altitude hypoxia
Break Coffee/Tea (20 mins)
泭
15:30-16:40 Circulation and innate immune response (70 mins) Prof Edwin Chilvers (Chair)
泭
Prof Alexander Gourine (UCL) Long Talk
Mechanisms of cerebral blood flow control during hypoxia
Dr Katharine Lodge (51勛圖厙) Long Talk
Neutrophil phenotype in hypoxia
Dr Charis Pericleous (51勛圖厙) Short talk
Modelling stroke in thrombotic antiphospholipid syndrome
Dr Lida Kabir (LMS-MRC 51勛圖厙) 泭Short talk
Crosstalk between AMP-activated protein kinase and hypoxia signalling in the endothelium