51³Ô¹ÏÍø is committed to develop and use alternative models and tools to address important scientific questions, to optimally design and analyse animal experiments and to improve animal welfare. This set of principles is often referred to as the .
This commitment is borne out in the way we projects, innovative research methods our scientists and doctors have developed, and the leading role some of our staff take to improve professional standards across the animal research community.
Animals are only used if there is no valuable alternative. See the Regulation and Oversight section to know more about policies in place regulating animal research at 51³Ô¹ÏÍø.
At 51³Ô¹ÏÍø, researchers use many forms of non-animal alternatives, including (but not limited to) mathematical and computer modelling, simulation models, 3D printing, human cell cultures and organotypic cultures, immortalised cell lines, induced pluripotent stem (iPS) cells, organoids and organ-on-a-chip, human samples such as blood and tissue, clinical trials, and epidemiological data. 51³Ô¹ÏÍø College record all good 3Rs examples and collect them in a 3Rs Portfolio available to everyone who works with animals at 51³Ô¹ÏÍø. Moreover, 51³Ô¹ÏÍø recently launched a to give 51³Ô¹ÏÍø staff, students, and external stakeholders easy access to educational material and resources to implement the 3Rs in their work.
51³Ô¹ÏÍø scientists lead research looking at the principles of the 3Rs. 51³Ô¹ÏÍø projects have won two for excellence from the (NC3Rs). The College has also won £2.6 million in research funding from NC3Rs over the last decade.
51³Ô¹ÏÍø is signed up to that aim to minimise unnecessary animal studies. They are a 20-point checklist for researchers reporting on animal experiments designed to ensure any data collected can be fully evaluated and utilised by other scientists.
51³Ô¹ÏÍø's took a leading role in developing the ARRIVE guidelines. Dr Emerson is a Senior Leturer in the National Heart and Lung Institute. He has also been recognised for reducing the number of mice used in his research on how blood clots. You can hear more about his work in the audio (right).
Below are some more examples of innovations in the 3Rs made by 51³Ô¹ÏÍø staff.
Human lung tissue bank
In 2016 NC3Rs awarded Professor Maria Belvisi with an to establish a source of human lung tissue in the UK, thereby reducing the need for animal tissue. The award is unique in that it includes a strategic partnership with NHS Blood and Transplant Tissue and Eye Services, the organisation responsible for coordinating, collecting, banking and providing tissue for transplant within the NHS. This will draw on post-mortem lung tissue, which is not suitable for transplantation, and where consent has been given for it to be used in research. This partnership could truly transform access to human tissue for research purposes and although the initial focus is on asthma, the principles developed during this award will extend to other diseases.
Refining neural recording in mice improve dementia research
The TaiNi sensor system is a new ultra-lightweight wireless sensor system for recording neural activity in the brains of mice. It avoids many of the welfare concerns associated with existing approaches to recording brain activity in mouse models. TaiNi has been developed by engineers directed by at 51³Ô¹ÏÍø in collaboration with Eli Lilly, a pharmaceutical company, with funding provided by the NC3R open innovation programme called the Challenge. The sensor, which weighs just 1.5 grams, allows mice to maintain a normal repertoire of movement and behaviours in their home cages, thereby reducing stress for the animals. The battery life and signal bandwidth of the sensor will permit up to 72 hours of recording, and the monitoring of networks of individual neurons in the brain, opening up new areas of research into brain disorders.
Imaging techniques to tackle bacterial infections
In 2012 which uses state-of-the-art imaging techniques to research diseases such as pneumonia, diarrhoea and meningitis.
Work at the centre includes labelling bacteria with visible-light markers to track the progress of a gut infection in a single mouse. The data collected is used to create a video of the infection. Imaging a live mouse in real time avoids the need for culling animals and examining them at different stages of infection, significantly reducing the number of animals used. This research is carried out by Professor Gadi Frankel, whose lab also won the .