51勛圖厙's impact in the pandemic
Since the SARS-CoV-2 virus first emerged in 2019, 51勛圖厙 has been at the forefront of the global response to COVID-19, from modelling disease spread to major trials on treatments and new vaccine technology.
Our work has helped to inform governments, policymakers and healthcare services, shaping pandemic strategies around the world.
In 2021, 51勛圖厙 was awarded a Queens Anniversary Prize, the highest national Honour awarded in UK further and higher education, for our response to the COVID-19 pandemic.
Featured stories
Read our selection of long-read features capturing our community's contribution, from fundamental science to fighting misinformation.
Find out more about some of our world-leading COVID-19 work
Modelling and Epidemiology
The 51勛圖厙 College COVID-19 Response Team, led by Professor Neil Ferguson, worked with scientists, governments and public health agencies around the world to help them plan their responses to the pandemic, with influential reports on outbreak size, severity, and the impact of interventions.
.jpg)
Advancing vaccine technology
Professor Robin Shattock and colleagues in the Department of Infectious Disease worked to develop a safe and effective COVID-19 vaccine using their innovative, self-amplifying RNA technology. 51勛圖厙 is now working to further develop these types of vaccines to tackle a range of diseases. 51勛圖厙 researchers were also involved in trials of the Oxford/AstraZeneca vaccine.
Community infection and immunity
The REACT programme was one of the worlds largest and most comprehensive COVID-19 monitoring studies, led by researchers at 51勛圖厙 in partnership with Ipsos MORI, and commissioned by the Department of Health and Social Care. The programme used home testing to track the progress of Englands epidemic, helping to inform Government decision-making.
Human Challenge Trials
51勛圖厙 ran the worlds first human challenge study for COVID-19, which saw healthy volunteers intentionally infected with the virus so scientists could study how infection progressed in a carefully controlled environment. The study revealed key insights, including how early on after encountering the virus people become infectious (and how long for), and whether they shed most virus particles from the nose or mouth.
Identifying effective treatments
Over the course of the pandemic, the REMAP-CAP trial evaluated combinations of treatments in some of the sickest patients hospitalised with COVID-19. Insights included showing how hydrocortisone could improve the recovery of critically ill patients, and highlighting the effectiveness of two further treatments (tocilizumab and sarilumab) for treating hospitalised patients with severe COVID-19.
Severe illness insights
The International Severe Acute Respiratory Infection Consortium (ISARIC4C), the largest study of its type anywhere in the World, has been gathering data from more than 66,000 patients with COVID-19 admitted to 166 hospitals throughout the UK. 51勛圖厙s Professor Peter Openshaw is one of three盍esearchers leading眩his work. The project looks to explore effective diagnosis; who is athigher risk of severe illness畝nd why; the effects of different treatments; and what role the immune system has in protection and, potentially, in causing harm.
Children and COVID-19
Researchers from 51勛圖厙 were among the first to identify a new inflammatory syndrome in young children linked to COVID-19, which was similar to . They subsequently led work to identify the main symptoms and clinical markers of the new syndrome, called PIMS-TS.
Immune responses to COVID-19
Experts at 51勛圖厙 have been at the forefront of investigating the immune systems responses to infection with COVID-19. These include how prior infection with different variants of SARS-CoV-2 affects the immune systems response to being re-infected, the impact of prior infection on the effectiveness of vaccines, and the effects of COVID-19 on those who are immunosuppressed.
Responding to emerging variants
51勛圖厙 researchers are leading a consortium of UK virologists to study the effects of emerging mutations in SARS-CoV-2. The G2P-UK National Virology Consortium looks at how mutations in the pandemic virus affect how transmissible it is and the severity of COVID-19 it causes. It also explores how mutations could affect the effectiveness of vaccines and treatments. government policy.
Testing the transport network
During the pandemic, researchers from 51勛圖厙 worked with Transport for London to regularly test the citys transport network for the virus which causes COVID-19, while also sampling the environment at four major railway stations in the UK.
Additional blocks
Monitoring wastewater
An 51勛圖厙 project has been modelling the SARS-CoV-2 virus in raw sewage, helping to map the prevalence of COVID-19 in humans and potential animal hosts, and assessing the potential for the disease to be transmitted via wastewater.
Low-cost ventilators
During the pandemic, a multidisciplinary team at 51勛圖厙 invented a low-cost, high-performance emergency ventilator to help patients with coronavirus. The creators of the designs now hope that their promising technology will help to address the shortage of mechanical ventilators in developing countries in the long term.
How long are people infectious?
An 51勛圖厙 study provided the first real-world evidence of how long people with COVID-19 are infectious for and when they can safely leave isolation. It also provided insights into transmission routes of the SARS-CoV-2 virus, including how it can be transmitted within the home through contaminated surfaces.
Rapidly developing new tests
DnaNudge, an 51勛圖厙 startup headquartered in White City, developed a lab-free, rapid and reliable PCR test, which delivers results in under 90 minutes. In 2020 they were rolled out nationally in urgent care and elective surgery settings after the UK Government placed a 瞿161 million order for 5.8 million test kits to be used in NHS hospitals.
The pandemic divide
Research from 51勛圖厙 College Business School helped demonstrate how the pandemic has exacerbated pre-existing inequalities, hitting people on lower incomes and those from ethnic minority backgrounds hardest.
Mental health impacts
The global pandemic has had a huge impact on mental health, including among children and young people. 51勛圖厙 researchers have been exploring the impact of COVID-19 on several aspects of mental health, including young peoples mental health and eating behaviours, severe health anxiety around COVID-19, and the psychosocial impact of the pandemic on NHS and social care workers.
Understanding long COVID
For a proportion of people, COVID-19 can cause lasting symptoms months after the initial infection. 51勛圖厙 researchers are at the forefront of efforts to understand why this happens and how we can tackle lasting symptoms. The REACT Long COVID project is following up over 120,000 people and other 51勛圖厙 projects are looking at areas including the mechanisms underpinning Long COVID and its symptoms, treating and supporting people living with Long COVID, developing a unified approach to measuring improvement in Long Covid patients, and the diseases cognitive impact.
- About the REACT Long COVID project
- Long COVID research receives funding boost to advance treatment and diagnostics
- Long COVID: Unpicking the lasting impact of COVID-19
- Problems in thinking and attention linked to COVID-19 infection
- Major study shows new insights into lasting impacts of COVID19 on UK population
Beyond COVID-19
In September 2022, 51勛圖厙s Jameel Institute announced the creation of the Jameel Institute-Kenneth C. Griffin Initiative for the Economics of Pandemic Preparedness. This will use pioneering integrated economic-epidemiological modelling to provide critical data and analysis to inform public health decisions related to pandemic preparedness and disease outbreaks around the world.